Category Archives: Drug action

New textbook chapter – Modelling Drug Induced Proarrhythmic Risk and a challenge for whole-heart computational modellers

Posted on July 20, 2023 by Gary Mirams

A little note to say that a textbook chapter I wrote last year is now online and available as part of the Springer Reference work “Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays“ The chapter is available here, and if … Continue reading →

Posted in Drug action, Safety Pharmacology, Tissue Simulations, Unexplained | Tagged , , , , , | Leave a comment

2023-2025 Postdoctoral Research Fellow positions available in our team (vacancies closed)

Posted on January 10, 2023 by Gary Mirams

N.B. Applications now closed. We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. You’ll be … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Future developments, Ion Channel Models, jobs, Model Development, Stats and Inference | Tagged , | Leave a comment

Postdoctoral Research Fellow positions available in our team (recruitment now closed)

Posted on March 8, 2022 by Gary Mirams

We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, jobs, Software, Stats and Inference | Tagged , , , , , , , | Leave a comment

2021 CiPA in-silico Modelling Workshop

Posted on June 14, 2021 by Gary Mirams

Abstract submission for the 2021 CiPA in-silico modelling meeting is open now. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , , , , , | Leave a comment

Job Available: Statistical inference for mechanistic models

Posted on October 4, 2019 by Gary Mirams

N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Job Available: Research Software Engineer

Posted on February 11, 2019 by Gary Mirams

Edit: please note the deadline for applications has now passed. Here’s a great opportunity to join our team at the University of Nottingham on a 5 year Research Software Engineering (RSE) position: https://www.nottingham.ac.uk/jobs/currentvacancies/ref/IS046219 The deadline for applications is 3rd March … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Numerics, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , | Leave a comment

Postdoctoral Research Positions Available

Posted on December 15, 2018 by Gary Mirams

N.B. 16th Jan 2019 – the applications for these positions are now closed. This post is to let people know about some opportunities for postdoctoral research here in the Centre for Mathematical Medicine & Biology, based in Mathematical Sciences, University … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Future developments, Ion Channel Models, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , | 1 Comment

A report on the Toronto CiPA in-silico modelling workshop

Posted on July 16, 2018 by Gary Mirams

This is a follow-up to this post advertising the workshop. On the 9th November 2017 the CiPA in-silico Working Group hosted a meeting in Toronto General Hospital that the Cardiac Physiome meeting kindly let us run as a satellite meeting … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , , , , , , | 2 Comments

Postdoc position available

Posted on September 4, 2017 by Gary Mirams

N.B. This position is now closed. Another short post, just to advertise a postdoctoral research associate (PDRA) position available to work with me. It’s a two year position, based at the Centre for Mathematical Medicine & Biology at the University … Continue reading →

Posted in Drug action, Experimental Design, Future developments, Ion Channel Models, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , | Leave a comment

CiPA in-silico modelling meeting

Posted on August 31, 2017 by Gary Mirams

There’s an effort underway to evaluate, improve and implement mathematical models of cardiac electrophysiology for pharmaceutical cardiac safety testing and regulatory practice. In particular, to be part of a more mechanistic and accurate in-vitro assessment of pro-arrhythmic risk than the … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , | 1 Comment