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Category Archives: Drug action
Job Available: Statistical inference for mechanistic models
N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading
Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference
Tagged Bayesian Inference, calibration, identifiability, inference, inverse problem, job, jobs, model complexity, model construction, model discrepancy, model selection, parameter fitting, validation
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Job Available: Research Software Engineer
Edit: please note the deadline for applications has now passed. Here’s a great opportunity to join our team at the University of Nottingham on a 5 year Research Software Engineering (RSE) position: https://www.nottingham.ac.uk/jobs/currentvacancies/ref/IS046219 The deadline for applications is 3rd March … Continue reading
Postdoctoral Research Positions Available
N.B. 16th Jan 2019 – the applications for these positions are now closed. This post is to let people know about some opportunities for postdoctoral research here in the Centre for Mathematical Medicine & Biology, based in Mathematical Sciences, University … Continue reading
A report on the Toronto CiPA insilico modelling workshop
This is a longawaited followup to this post advertising the workshop. Apologies it has taken so long, the fact I wanted to write something about the next meeting, which we just had, reminded me I never posted all these talks. … Continue reading
Postdoc position available
N.B. This position is now closed. Another short post, just to advertise a postdoctoral research associate (PDRA) position available to work with me. It’s a two year position, based at the Centre for Mathematical Medicine & Biology at the University … Continue reading
CiPA insilico modelling meeting
There’s an effort underway to evaluate, improve and implement mathematical models of cardiac electrophysiology for pharmaceutical cardiac safety testing and regulatory practice. In particular, to be part of a more mechanistic and accurate invitro assessment of proarrhythmic risk than the … Continue reading
Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?
On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased druginduced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading
Uncertainty quantification for ion channel screening and risk prediction
This post accompanies our new paper in Wellcome Open Research. Regular readers of this blog will know that I worry about uncertainty in the numbers we are using to model drug action on electrophysiology quite a lot – see our … Continue reading
Should I work with IC50s or pIC50s?
When you are expressing how much a drug inhibits something, it’s common to fit a Hill curve through a graph of concentration against % inhibition as shown here: In our case this is often ‘% inhibition’ for a given ionic … Continue reading
Are 30 compounds enough to test our simulations?
I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading