-
Recent Posts
- 2024-2025 Postdoctoral Research Positions – Applications closed
- New textbook chapter – Modelling Drug Induced Proarrhythmic Risk and a challenge for whole-heart computational modellers
- 2023-2025 Postdoctoral Research Fellow positions available in our team (vacancies closed)
- Englishman in New York (travel tips for Brits in the USA)
- Postdoctoral Research Fellow positions available in our team (recruitment now closed)
Archived posts
Tag cloud
- ablation
- Action potential
- alpine cyclamen
- APD
- Bayesian Inference
- benchmark
- bidomain
- block
- calibration
- Cardiac electrophysiology
- CellML
- CiPA
- concentration-effect
- conductances
- curation
- dose-response
- drug
- Drug action
- Drug safety
- ECG
- Finite element
- finite element meshes
- finite element simulations
- Functional Curation
- Future
- hERG
- high-throughput
- Hypothesis
- IC50
- identifiability
- IKr
- inference
- initial conditions
- inverse problem
- ion channel
- ion current
- job
- jobs
- logistic
- log logistic
- Meshing
- model
- model comparison
- model complexity
- model construction
- Models
- model selection
- mouse
- numerical methods
- ODE solving
- open questions
- opinion
- parameter fitting
- pIC50
- QT
- Safety pharmacology
- scar
- screening
- SED-ML
- sensitivity
- sensitivity analysis
- Silly
- simulation
- standing wave
- steady state
- tetrahedral mesh
- tetrahedral meshes
- tissue simulation
- Torsade
- training
- uncertainty
- validation
- Virtual experiments
- wave
- Web Lab
Categories
Follow me on Twitter
My TweetsBlog Stats
- 32,761 hits
RSS Feeds
-
Join 627 other subscribers
Wordpress Links
Tag Archives: model construction
2024-2025 Postdoctoral Research Positions – Applications closed
Edit: Jan 2024 – applications for these positions are now closed We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the … Continue reading
Posted in jobs
Tagged Cardiac electrophysiology, Drug safety, ion channel, job, model construction, parameter fitting
Leave a comment
Postdoctoral Research Fellow positions available in our team (recruitment now closed)
We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading
Job Available: Statistical inference for mechanistic models
N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading
Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference
Tagged Bayesian Inference, calibration, identifiability, inference, inverse problem, job, jobs, model complexity, model construction, model discrepancy, model selection, parameter fitting, validation
Leave a comment
Hodgkin-Huxley models and Markov equivalents
Hodgkin & Huxley did some incredible work in the 1930s-50s on ion currents flowing through biological membranes. Despite not knowing what an ion channel was, they managed to work out an incredibly accurate predictive mathematical model for the currents that … Continue reading
Posted in Ion Channel Models
Tagged electrophysiology, Hodgkin-Huxley, ion channel, ion current, Markov, model construction, Models
Leave a comment
Short and rich voltage-clamp protocols
This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading
Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference
Tagged Bayesian Inference, Cardiac electrophysiology, hERG, identifiability, IKr, inference, inverse problem, ion channel, model, model construction, parameter fitting, parameterisation, validation
8 Comments
Ablation, scars and insights from parameter lumping
This is quite a long post elaborating on a bit of work I’ve been doing with Greg Morley and his group, which was published in Scientific Reports. I hope it provides an accessible introduction to a fairly complicated set of experiments … Continue reading
Is your model really ‘comprehensive’?
I’ve noticed more and more papers using the phrase “comprehensive model”. This phrase grates every time, and this post is about why. I thought this might just be me getting old and grumpy, so I plotted the mentions of the … Continue reading
Posted in Blog, Model Development, Silly
Tagged model comparison, model construction, Models, opinion, Silly, validation
Leave a comment
Job Advert
A quick shameless plug for a job we are advertising. This is a 3 year postdoctoral position to work with me in the Computational Biology Group in the Department of Computer Science, University of Oxford. It would best suit someone … Continue reading
Posted in Future developments
Tagged inference, inverse problem, job, model comparison, model construction, parameter fitting, uncertainty
Leave a comment
Hypotheses on hypotheses on …
(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading
Mathematical Matters of the Heart 