Tag Archives: inference

Numerical errors from ODE solvers can mess up optimisation and inference very easily

(Subtitle: “when you’ve got a lot of data points!”) This post is for people interested in doing optimisation or inference with Differential Equation (DE) models. If you are a statistician, you might be used to treating model simulators as black … Continue reading

Posted in Action Potential Models, Numerics, Stats and Inference | Tagged , , , , , , , | 5 Comments

Short and rich voltage-clamp protocols

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 3 Comments

Uncertainty quantification for ion channel screening and risk prediction

This post accompanies our new paper in Wellcome Open Research. Regular readers of this blog will know that I worry about uncertainty in the numbers we are using to model drug action on electrophysiology quite a lot – see our … Continue reading

Posted in Drug action, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , , | 4 Comments

Model Complexity

We’ve been thinking about how to parameterise/train/calibrate models, and also how to select an appropriate model to begin with. This raises all sorts of interesting questions on the details, but this post is just about setting out a big overview … Continue reading

Posted in Action Potential Models, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , | 2 Comments

Job Advert

A quick shameless plug for a job we are advertising. This is a 3 year postdoctoral position to work with me in the Computational Biology Group in the Department of Computer Science, University of Oxford. It would best suit someone … Continue reading

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