Tag Archives: inference

Postdoctoral Research Fellow positions available in our team (recruitment now closed)

Posted on March 8, 2022 by Gary Mirams

We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, jobs, Software, Stats and Inference | Tagged , , , , , , , | Leave a comment

Our new review on fitting cardiac models

Posted on February 28, 2020 by Gary Mirams

A reasonably short post to let you know about our recently published paper in WIREs Systems Biology and Medicine on parameter fitting in cardiac ion channel and action potential models with David Christini. There is an accessible introductory news article … Continue reading →

Posted in Action Potential Models, Experimental Design, Ion Channel Models, Model Development, Stats and Inference, Uncategorized | Tagged , , , , , , , | Leave a comment

Job Available: Statistical inference for mechanistic models

Posted on October 4, 2019 by Gary Mirams

N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Numerical errors from ODE solvers can mess up optimisation and inference very easily

Posted on October 17, 2018 by Gary Mirams

(Subtitle: “when you’ve got a lot of data points!”) This post is for people interested in doing optimisation or inference with Differential Equation (DE) models. If you are a statistician, you might be used to treating model simulators as black … Continue reading →

Posted in Action Potential Models, Numerics, Stats and Inference | Tagged , , , , , , , | 7 Comments

Short and rich voltage-clamp protocols

Posted on May 2, 2018 by Gary Mirams

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 8 Comments

Uncertainty quantification for ion channel screening and risk prediction

Posted on November 23, 2016 by Gary Mirams

This post accompanies our new paper in Wellcome Open Research. Regular readers of this blog will know that I worry about uncertainty in the numbers we are using to model drug action on electrophysiology quite a lot – see our … Continue reading →

Posted in Drug action, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , , | 4 Comments

Model Complexity

Posted on October 20, 2015 by Gary Mirams

We’ve been thinking about how to parameterise/train/calibrate models, and also how to select an appropriate model to begin with. This raises all sorts of interesting questions on the details, but this post is just about setting out a big overview … Continue reading →

Posted in Action Potential Models, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , | 3 Comments

Job Advert

Posted on June 26, 2015 by Gary Mirams

A quick shameless plug for a job we are advertising. This is a 3 year postdoctoral position to work with me in the Computational Biology Group in the Department of Computer Science, University of Oxford. It would best suit someone … Continue reading →

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