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Tag Archives: inverse problem
Job Available: Statistical inference for mechanistic models
N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading
Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference
Tagged Bayesian Inference, calibration, identifiability, inference, inverse problem, job, jobs, model complexity, model construction, model discrepancy, model selection, parameter fitting, validation
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Three potassium channel modelling papers
Just a quick note to tell you about our latest batch of papers in the “Heart By Numbers” special issue of Biophysical Journal which arose from a meeting in Berlin last year. They are all about IKr, the rapid-delayed rectifying … Continue reading
Short and rich voltage-clamp protocols
This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading
Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference
Tagged Bayesian Inference, Cardiac electrophysiology, hERG, identifiability, IKr, inference, inverse problem, ion channel, model, model construction, parameter fitting, parameterisation, validation
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Job Advert
A quick shameless plug for a job we are advertising. This is a 3 year postdoctoral position to work with me in the Computational Biology Group in the Department of Computer Science, University of Oxford. It would best suit someone … Continue reading
Posted in Future developments
Tagged inference, inverse problem, job, model comparison, model construction, parameter fitting, uncertainty
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Triangles and Conductances
Just a little post on something that’s really simple, not new, and might seem obvious to some people – but might help when choosing how to explore the effect of altering parameters on action potential model behaviour. The reason I … Continue reading
Mathematical Matters of the Heart 