Category Archives: Numerics

Job Available: Statistical inference for mechanistic models

Posted on October 4, 2019 by Gary Mirams

N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Three potassium channel modelling papers

Posted on September 8, 2019 by Gary Mirams

Just a quick note to tell you about our latest batch of papers in the “Heart By Numbers” special issue of Biophysical Journal which arose from a meeting in Berlin last year. They are all about IKr, the rapid-delayed rectifying … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , | 3 Comments

Job Available: Research Software Engineer

Posted on February 11, 2019 by Gary Mirams

Edit: please note the deadline for applications has now passed. Here’s a great opportunity to join our team at the University of Nottingham on a 5 year Research Software Engineering (RSE) position: https://www.nottingham.ac.uk/jobs/currentvacancies/ref/IS046219 The deadline for applications is 3rd March … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Numerics, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , | Leave a comment

Numerical errors from ODE solvers can mess up optimisation and inference very easily

Posted on October 17, 2018 by Gary Mirams

(Subtitle: “when you’ve got a lot of data points!”) This post is for people interested in doing optimisation or inference with Differential Equation (DE) models. If you are a statistician, you might be used to treating model simulators as black … Continue reading →

Posted in Action Potential Models, Numerics, Stats and Inference | Tagged , , , , , , , | 7 Comments

ODE solving for cardiac action potential models

Posted on December 12, 2014 by Gary Mirams

Just a quick post to highlight a new paper by Jon Cooper, Ray Spiteri and me, which describes the use of Chaste and CellML to solve cardiac action potential model equations. The paper in Frontiers in Physiology is in a … Continue reading →

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Initial conditions and steady states

Posted on July 22, 2014 by Gary Mirams

Today I came across a good (or bad, depending on how you look at it) example of initial conditions / steady-states having a massive effect on model behaviour. I think it is generally a good idea to get a model … Continue reading →

Posted in Action Potential Models, Drug action, Numerics, Virtual Experiments | Tagged , , , , , , , | 3 Comments