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Recent Posts
- 2024-2025 Postdoctoral Research Positions – Applications closed
- New textbook chapter – Modelling Drug Induced Proarrhythmic Risk and a challenge for whole-heart computational modellers
- 2023-2025 Postdoctoral Research Fellow positions available in our team (vacancies closed)
- Englishman in New York (travel tips for Brits in the USA)
- Postdoctoral Research Fellow positions available in our team (recruitment now closed)
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Author Archives: Gary Mirams
2024-2025 Postdoctoral Research Positions – Applications closed
Edit: Jan 2024 – applications for these positions are now closed We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the … Continue reading
Posted in jobs
Tagged Cardiac electrophysiology, Drug safety, ion channel, job, model construction, parameter fitting
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New textbook chapter – Modelling Drug Induced Proarrhythmic Risk and a challenge for whole-heart computational modellers
A little note to say that a textbook chapter I wrote last year is now online and available as part of the Springer Reference work “Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays“ The chapter is available here, and if … Continue reading
2023-2025 Postdoctoral Research Fellow positions available in our team (vacancies closed)
N.B. Applications now closed. We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. You’ll be … Continue reading
Englishman in New York (travel tips for Brits in the USA)
One of my UK students is going to visit the USA soon, so I promised this overdue blog. As a Brit visiting the USA there are certain things that can leave you a bit baffled, that just work differently (I’m … Continue reading
Postdoctoral Research Fellow positions available in our team (recruitment now closed)
We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading
Research Software Engineer (C++ and HPC) position available (recruitment now closed).
Regular readers might know I’m one of the developers and users of Chaste – Cancer, Heart and Soft Tissue Environment, a C++ library for computational cell biology and physiology problems including cardiac simulations, lung airway simulations and individual-cell based modelling. … Continue reading
2021 CiPA in-silico Modelling Workshop
Abstract submission for the 2021 CiPA in-silico modelling meeting is open now. Continue reading
Our new review on fitting cardiac models
A reasonably short post to let you know about our recently published paper in WIREs Systems Biology and Medicine on parameter fitting in cardiac ion channel and action potential models with David Christini. There is an accessible introductory news article … Continue reading
Job Available: Statistical inference for mechanistic models
N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading
Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference
Tagged Bayesian Inference, calibration, identifiability, inference, inverse problem, job, jobs, model complexity, model construction, model discrepancy, model selection, parameter fitting, validation
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Hodgkin-Huxley models and Markov equivalents
Hodgkin & Huxley did some incredible work in the 1930s-50s on ion currents flowing through biological membranes. Despite not knowing what an ion channel was, they managed to work out an incredibly accurate predictive mathematical model for the currents that … Continue reading
Posted in Ion Channel Models
Tagged electrophysiology, Hodgkin-Huxley, ion channel, ion current, Markov, model construction, Models
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Mathematical Matters of the Heart 