Category Archives: Future developments

Three potassium channel modelling papers

Just a quick note to tell you about our latest batch of papers in the “Heart By Numbers” special issue of Biophysical Journal which arose from a meeting in Berlin last year. They are all about IKr, the rapid-delayed rectifying … Continue reading

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Job Available: Research Software Engineer

Edit: please note the deadline for applications has now passed. Here’s a great opportunity to join our team at the University of Nottingham on a 5 year Research Software Engineering (RSE) position: https://www.nottingham.ac.uk/jobs/currentvacancies/ref/IS046219 The deadline for applications is 3rd March … Continue reading

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Postdoctoral Research Positions Available

N.B. 16th Jan 2019 – the applications for these positions are now closed. This post is to let people know about some opportunities for postdoctoral research here in the Centre for Mathematical Medicine & Biology, based in Mathematical Sciences, University … Continue reading

Posted in Action Potential Models, Drug action, Experimental Design, Future developments, Ion Channel Models, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , | 1 Comment

A report on the Toronto CiPA in-silico modelling workshop

This is a follow-up to this post advertising the workshop. On the 9th November 2017 the CiPA in-silico Working Group hosted a meeting in Toronto General Hospital that the Cardiac Physiome meeting kindly let us run as a satellite meeting … Continue reading

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Short and rich voltage-clamp protocols

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading

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Postdoc position available

N.B. This position is now closed. Another short post, just to advertise a postdoctoral research associate (PDRA) position available to work with me. It’s a two year position, based at the Centre for Mathematical Medicine & Biology at the University … Continue reading

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CiPA in-silico modelling meeting

There’s an effort underway to evaluate, improve and implement mathematical models of cardiac electrophysiology for pharmaceutical cardiac safety testing and regulatory practice. In particular, to be part of a more mechanistic and accurate in-vitro assessment of pro-arrhythmic risk than the … Continue reading

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Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading

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Ablation, scars and insights from parameter lumping

This is quite a long post elaborating on a bit of work I’ve been doing with Greg Morley and his group, which was published in Scientific Reports. I hope it provides an accessible introduction to a fairly complicated set of experiments … Continue reading

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Job Advert

A quick shameless plug for a job we are advertising. This is a 3 year postdoctoral position to work with me in the Computational Biology Group in the Department of Computer Science, University of Oxford. It would best suit someone … Continue reading

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