-
Recent Posts
Archived posts
Tag cloud
ablation Action potential alpine cyclamen APD Bayesian benchmark bidomain block calibration Cardiac electrophysiology CellML CiPA concentration-effect conductances connexin curation disease dose-response drug Drug action Drug safety ECG Finite element finite element meshes finite element simulations Functional Curation Future gap junctions Hypothesis IC50 identifiability inference initial conditions inverse problem ion channel ion current job logistic log logistic Meshing model model comparison model complexity model construction Models model selection monodomain mouse New Paper ODE solving open questions opinion parameter fitting pIC50 QT safety Safety pharmacology scar screening SED-ML sensitivity sensitivity analysis Silly simulation standing wave steady state tetrahedral mesh tetrahedral meshes tissue simulation training uncertainty validation Virtual experiments wave Web LabCategories
Follow me on Twitter
My TweetsBlog Stats
- 8,964 hits
RSS Feeds
Wordpress Links
Category Archives: Future developments
Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?
On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading
Ablation, scars and insights from parameter lumping
This is quite a long post elaborating on a bit of work I’ve been doing with Greg Morley and his group, which was published in Scientific Reports. I hope it provides an accessible introduction to a fairly complicated set of experiments … Continue reading
Job Advert
A quick shameless plug for a job we are advertising. This is a 3 year postdoctoral position to work with me in the Computational Biology Group in the Department of Computer Science, University of Oxford. It would best suit someone … Continue reading
Posted in Future developments
Tagged inference, inverse problem, job, model comparison, model construction, parameter fitting, uncertainty
Leave a comment
Hypotheses on hypotheses on …
(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading
A vision of the future
Jonathan Cooper and I have been working on a system for describing the simulation you would like to perform with a model*, in a way that is flexible enough to recreate the majority of possible experiments and post-processing, and machine-readable … Continue reading
