Tag Archives: Cardiac electrophysiology

2024-2025 Postdoctoral Research Positions – Applications closed

Posted on December 13, 2023 by Gary Mirams

Edit: Jan 2024 – applications for these positions are now closed We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the … Continue reading →

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New textbook chapter – Modelling Drug Induced Proarrhythmic Risk and a challenge for whole-heart computational modellers

Posted on July 20, 2023 by Gary Mirams

A little note to say that a textbook chapter I wrote last year is now online and available as part of the Springer Reference work “Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays“ The chapter is available here, and if … Continue reading →

Posted in Drug action, Safety Pharmacology, Tissue Simulations, Unexplained | Tagged , , , , , | Leave a comment

2023-2025 Postdoctoral Research Fellow positions available in our team (vacancies closed)

Posted on January 10, 2023 by Gary Mirams

N.B. Applications now closed. We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. You’ll be … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Future developments, Ion Channel Models, jobs, Model Development, Stats and Inference | Tagged , | Leave a comment

Postdoctoral Research Fellow positions available in our team (recruitment now closed)

Posted on March 8, 2022 by Gary Mirams

We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading →

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2021 CiPA in-silico Modelling Workshop

Posted on June 14, 2021 by Gary Mirams

Abstract submission for the 2021 CiPA in-silico modelling meeting is open now. Continue reading →

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Short and rich voltage-clamp protocols

Posted on May 2, 2018 by Gary Mirams

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 8 Comments

Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

Posted on March 27, 2017 by Gary Mirams

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Model Development, Safety Pharmacology, Tissue Simulations | Tagged , , , , , , , | 3 Comments

Are 30 compounds enough to test our simulations?

Posted on February 24, 2016 by Gary Mirams

I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading →

Posted in Action Potential Models, Drug action, Ion Channel Models, Safety Pharmacology, Stats and Inference | Tagged , , , , | 7 Comments

Triangles and Conductances

Posted on June 8, 2015 by Gary Mirams

Just a little post on something that’s really simple, not new, and might seem obvious to some people – but might help when choosing how to explore the effect of altering parameters on action potential model behaviour. The reason I … Continue reading →

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Hypotheses on hypotheses on …

Posted on May 25, 2015 by Gary Mirams

(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading →

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