Tag Archives: validation

Our new review on fitting cardiac models

Posted on February 28, 2020 by Gary Mirams

A reasonably short post to let you know about our recently published paper in WIREs Systems Biology and Medicine on parameter fitting in cardiac ion channel and action potential models with David Christini. There is an accessible introductory news article … Continue reading →

Posted in Action Potential Models, Experimental Design, Ion Channel Models, Model Development, Stats and Inference, Uncategorized | Tagged , , , , , , , | Leave a comment

Job Available: Statistical inference for mechanistic models

Posted on October 4, 2019 by Gary Mirams

N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading →

Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Short and rich voltage-clamp protocols

Posted on May 2, 2018 by Gary Mirams

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 8 Comments

Is your model really ‘comprehensive’?

Posted on May 5, 2016 by Gary Mirams

I’ve noticed more and more papers using the phrase “comprehensive model”. This phrase grates every time, and this post is about why. I thought this might just be me getting old and grumpy, so I plotted the mentions of the … Continue reading →

Posted in Blog, Model Development, Silly | Tagged , , , , , | Leave a comment

Are 30 compounds enough to test our simulations?

Posted on February 24, 2016 by Gary Mirams

I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading →

Posted in Action Potential Models, Drug action, Ion Channel Models, Safety Pharmacology, Stats and Inference | Tagged , , , , | 7 Comments

Model Complexity

Posted on October 20, 2015 by Gary Mirams

We’ve been thinking about how to parameterise/train/calibrate models, and also how to select an appropriate model to begin with. This raises all sorts of interesting questions on the details, but this post is just about setting out a big overview … Continue reading →

Posted in Action Potential Models, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , | 3 Comments