Category Archives: Stats and Inference

Short and rich voltage-clamp protocols

Posted on May 2, 2018 by

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Postdoc position available

Posted on September 4, 2017 by

Another short post, just to advertise a postdoctoral research associate (PDRA) position available to work with me. It’s a two year position, based at the Centre for Mathematical Medicine & Biology at the University of Nottingham, with the potential to … Continue reading →

Posted in Drug action, Experimental Design, Future developments, Ion Channel Models, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , | Leave a comment

Uncertainty quantification for ion channel screening and risk prediction

Posted on November 23, 2016 by

This post accompanies our new paper in Wellcome Open Research. Regular readers of this blog will know that I worry about uncertainty in the numbers we are using to model drug action on electrophysiology quite a lot – see our … Continue reading →

Posted in Drug action, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , , | 4 Comments

Should I work with IC50s or pIC50s?

Posted on June 13, 2016 by

When you are expressing how much a drug inhibits something, it’s common to fit a Hill curve through a graph of concentration against % inhibition as shown here: In our case this is often ‘% inhibition’ for a given ionic … Continue reading →

Posted in Drug action, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , , , , , | 1 Comment

Are 30 compounds enough to test our simulations?

Posted on February 24, 2016 by

I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading →

Posted in Action Potential Models, Drug action, Ion Channel Models, Safety Pharmacology, Stats and Inference | Tagged , , , , | 7 Comments

Model Complexity

Posted on October 20, 2015 by

We’ve been thinking about how to parameterise/train/calibrate models, and also how to select an appropriate model to begin with. This raises all sorts of interesting questions on the details, but this post is just about setting out a big overview … Continue reading →

Posted in Action Potential Models, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , | 1 Comment

If computational biologists did astronomy…

Posted on September 12, 2015 by

Here is a cheeky post along the lines of Can a biologist fix a radio? (well worth a read). The discovery that Pluto wasn’t the size we expected got me thinking about how we would have tackled it. So in … Continue reading →

Posted in Action Potential Models, Silly, Stats and Inference | Tagged , , , | Leave a comment