Tag Archives: ion channel

Short and rich voltage-clamp protocols

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Uncertainty quantification for ion channel screening and risk prediction

This post accompanies our new paper in Wellcome Open Research. Regular readers of this blog will know that I worry about uncertainty in the numbers we are using to model drug action on electrophysiology quite a lot – see our … Continue reading

Posted in Drug action, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , , | 4 Comments

A vision of the future

Jonathan Cooper and I have been working on a system for describing the simulation you would like to perform with a model*, in a way that is flexible enough to recreate the majority of possible experiments and post-processing, and machine-readable … Continue reading

Posted in Future developments, Virtual Experiments | Tagged , , , , , , , | 2 Comments

Action potential durations and QT intervals

Here’s an interesting little result that is thanks to Kylie. She found it whilst doing the work for her paper on prediction of drug compound effects at the tissue scale using data on multiple ion channel block. But we didn’t … Continue reading

Posted in Action Potential Models, Drug action, Tissue Simulations | Tagged , , , , , , | 7 Comments