Tag Archives: ion channel

2024-2025 Postdoctoral Research Positions – Applications closed

Posted on December 13, 2023 by Gary Mirams

Edit: Jan 2024 – applications for these positions are now closed We are looking for new members to join our Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the … Continue reading →

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Postdoctoral Research Fellow positions available in our team (recruitment now closed)

Posted on March 8, 2022 by Gary Mirams

We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, jobs, Software, Stats and Inference | Tagged , , , , , , , | Leave a comment

2021 CiPA in-silico Modelling Workshop

Posted on June 14, 2021 by Gary Mirams

Abstract submission for the 2021 CiPA in-silico modelling meeting is open now. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , , , , , | Leave a comment

Hodgkin-Huxley models and Markov equivalents

Posted on September 30, 2019 by Gary Mirams

Hodgkin & Huxley did some incredible work in the 1930s-50s on ion currents flowing through biological membranes. Despite not knowing what an ion channel was, they managed to work out an incredibly accurate predictive mathematical model for the currents that … Continue reading →

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Three potassium channel modelling papers

Posted on September 8, 2019 by Gary Mirams

Just a quick note to tell you about our latest batch of papers in the “Heart By Numbers” special issue of Biophysical Journal which arose from a meeting in Berlin last year. They are all about IKr, the rapid-delayed rectifying … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , | 3 Comments

Short and rich voltage-clamp protocols

Posted on May 2, 2018 by Gary Mirams

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 8 Comments

Uncertainty quantification for ion channel screening and risk prediction

Posted on November 23, 2016 by Gary Mirams

This post accompanies our new paper in Wellcome Open Research. Regular readers of this blog will know that I worry about uncertainty in the numbers we are using to model drug action on electrophysiology quite a lot – see our … Continue reading →

Posted in Drug action, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , , , , , , , , | 4 Comments

A vision of the future

Posted on April 2, 2014 by Gary Mirams

Jonathan Cooper and I have been working on a system for describing the simulation you would like to perform with a model*, in a way that is flexible enough to recreate the majority of possible experiments and post-processing, and machine-readable … Continue reading →

Posted in Future developments, Virtual Experiments | Tagged , , , , , , , | 2 Comments

Action potential durations and QT intervals

Posted on March 21, 2014 by Gary Mirams

Here’s an interesting little result that is thanks to Kylie. She found it whilst doing the work for her paper on prediction of drug compound effects at the tissue scale using data on multiple ion channel block. But we didn’t … Continue reading →

Posted in Action Potential Models, Drug action, Tissue Simulations | Tagged , , , , , , | 7 Comments