Category Archives: Tissue Simulations

Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading

Posted in Action Potential Models, Drug action, Future developments, Model Development, Safety Pharmacology, Tissue Simulations | Tagged , , , , , , , | 1 Comment

Ablation, scars and insights from parameter lumping

This is quite a long post elaborating on a bit of work I’ve been doing with Greg Morley and his group, which was published in Scientific Reports. I hope it provides an accessible introduction to a fairly complicated set of experiments … Continue reading

Posted in Action Potential Models, Future developments, Model Development, Tissue Simulations | Tagged , , , , , , , , , , | Leave a comment

Hypotheses on hypotheses on …

(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading

Posted in Action Potential Models, Future developments, Tissue Simulations | Tagged , , , , , | Leave a comment

ODE solving for cardiac action potential models

Just a quick post to highlight a new paper by Jon Cooper, Ray Spiteri and me, which describes the use of Chaste and CellML to solve cardiac action potential model equations. The paper in Frontiers in Physiology is in a … Continue reading

Posted in Action Potential Models, Numerics, Tissue Simulations | Tagged , , , | Leave a comment

Action potential durations and QT intervals

Here’s an interesting little result that is thanks to Kylie. She found it whilst doing the work for her paper on prediction of drug compound effects at the tissue scale using data on multiple ion channel block. But we didn’t … Continue reading

Posted in Action Potential Models, Drug action, Tissue Simulations | Tagged , , , , , , | 7 Comments

A standing cardiac electrical wave…?

Here’s my first post on an unexplained result. Normally at a ‘steady pacing’ rate cardiac tissue will recover enough to let the next wave through. But there’s a maximum rate you can achieve: if you try to pace faster than … Continue reading

Posted in Action Potential Models, Tissue Simulations, Unexplained | Tagged , , , , , | 1 Comment

Quick and easy meshing…

I have never come across any (free) 3D meshing software that is really quick and easy to use that creates reliable tetrahedral meshes. If you have, then please let me know in the comments! DistMesh The nearest thing I have … Continue reading

Posted in Tissue Simulations | Tagged , , , , , , | 1 Comment