Tag Archives: Action potential

Postdoctoral Research Fellow positions available in our team (recruitment now closed)

Posted on March 8, 2022 by Gary Mirams

We are looking for new members to join a Wellcome-funded team of cardiac electrophysiology modellers, to develop mathematical models of ion channel currents and cardiac cells for assessing the safety of new pharmaceutical drugs. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, jobs, Software, Stats and Inference | Tagged , , , , , , , | Leave a comment

2021 CiPA in-silico Modelling Workshop

Posted on June 14, 2021 by Gary Mirams

Abstract submission for the 2021 CiPA in-silico modelling meeting is open now. Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , , , , , | Leave a comment

A report on the Toronto CiPA in-silico modelling workshop

Posted on July 16, 2018 by Gary Mirams

This is a follow-up to this post advertising the workshop. On the 9th November 2017 the CiPA in-silico Working Group hosted a meeting in Toronto General Hospital that the Cardiac Physiome meeting kindly let us run as a satellite meeting … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , , , , , , | 2 Comments

Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

Posted on March 27, 2017 by Gary Mirams

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading →

Posted in Action Potential Models, Drug action, Future developments, Model Development, Safety Pharmacology, Tissue Simulations | Tagged , , , , , , , | 3 Comments

Are 30 compounds enough to test our simulations?

Posted on February 24, 2016 by Gary Mirams

I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading →

Posted in Action Potential Models, Drug action, Ion Channel Models, Safety Pharmacology, Stats and Inference | Tagged , , , , | 7 Comments

Triangles and Conductances

Posted on June 8, 2015 by Gary Mirams

Just a little post on something that’s really simple, not new, and might seem obvious to some people – but might help when choosing how to explore the effect of altering parameters on action potential model behaviour. The reason I … Continue reading →

Posted in Action Potential Models, Drug action | Tagged , , , , , , | 2 Comments

Hypotheses on hypotheses on …

Posted on May 25, 2015 by Gary Mirams

(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading →

Posted in Action Potential Models, Future developments, Tissue Simulations | Tagged , , , , , | Leave a comment

ODE solving for cardiac action potential models

Posted on December 12, 2014 by Gary Mirams

Just a quick post to highlight a new paper by Jon Cooper, Ray Spiteri and me, which describes the use of Chaste and CellML to solve cardiac action potential model equations. The paper in Frontiers in Physiology is in a … Continue reading →

Posted in Action Potential Models, Numerics, Tissue Simulations | Tagged , , , | Leave a comment

In-silico Action Potential Prediction Web Portal

Posted on July 23, 2014 by Gary Mirams

This post is to announce that we are making our in-silico action potential prediction web portal (AP-predict) available for public use. The portal is free, you just need to register for an account. We’d be happy to have any feedback on … Continue reading →

Posted in Action Potential Models, Drug action, Safety Pharmacology | Tagged , , , , , , , | Leave a comment

Initial conditions and steady states

Posted on July 22, 2014 by Gary Mirams

Today I came across a good (or bad, depending on how you look at it) example of initial conditions / steady-states having a massive effect on model behaviour. I think it is generally a good idea to get a model … Continue reading →

Posted in Action Potential Models, Drug action, Numerics, Virtual Experiments | Tagged , , , , , , , | 3 Comments