Tag Archives: Action potential

A report on the Toronto CiPA in-silico modelling workshop

This is a long-awaited follow-up to this post advertising the workshop. Apologies it has taken so long, the fact I wanted to write something about the next meeting, which we just had, reminded me I never posted all these talks. … Continue reading

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Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading

Posted in Action Potential Models, Drug action, Future developments, Model Development, Safety Pharmacology, Tissue Simulations | Tagged , , , , , , , | 2 Comments

Are 30 compounds enough to test our simulations?

I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading

Posted in Action Potential Models, Drug action, Ion Channel Models, Safety Pharmacology, Stats and Inference | Tagged , , , , | 7 Comments

Triangles and Conductances

Just a little post on something that’s really simple, not new, and might seem obvious to some people – but might help when choosing how to explore the effect of altering parameters on action potential model behaviour. The reason I … Continue reading

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Hypotheses on hypotheses on …

(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading

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ODE solving for cardiac action potential models

Just a quick post to highlight a new paper by Jon Cooper, Ray Spiteri and me, which describes the use of Chaste and CellML to solve cardiac action potential model equations. The paper in Frontiers in Physiology is in a … Continue reading

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In-silico Action Potential Prediction Web Portal

This post is to announce that we are making our in-silico action potential prediction web portal (AP-predict) available for public use. The portal is free, you just need to register for an account. We’d be happy to have any feedback on … Continue reading

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