Tag Archives: CiPA

Postdoc position available

Another short post, just to advertise a postdoctoral research associate (PDRA) position available to work with me. It’s a two year position, based at the Centre for Mathematical Medicine & Biology at the University of Nottingham, with the potential to … Continue reading

Posted in Drug action, Experimental Design, Future developments, Ion Channel Models, Model Development, Safety Pharmacology, Stats and Inference | Tagged , , | Leave a comment

CiPA in-silico modelling meeting

There’s an effort underway to evaluate, improve and implement mathematical models of cardiac electrophysiology for pharmaceutical cardiac safety testing and regulatory practice. In particular, to be part of a more mechanistic and accurate in-vitro assessment of pro-arrhythmic risk than the … Continue reading

Posted in Action Potential Models, Drug action, Future developments, Ion Channel Models, Model Development, Safety Pharmacology | Tagged , , | Leave a comment

Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading

Posted in Action Potential Models, Drug action, Future developments, Model Development, Safety Pharmacology, Tissue Simulations | Tagged , , , , , , , | 1 Comment