Tag Archives: model

New textbook chapter – Modelling Drug Induced Proarrhythmic Risk and a challenge for whole-heart computational modellers

Posted on July 20, 2023 by Gary Mirams

A little note to say that a textbook chapter I wrote last year is now online and available as part of the Springer Reference work “Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays“ The chapter is available here, and if … Continue reading →

Posted in Drug action, Safety Pharmacology, Tissue Simulations, Unexplained | Tagged , , , , , | Leave a comment

Three potassium channel modelling papers

Posted on September 8, 2019 by Gary Mirams

Just a quick note to tell you about our latest batch of papers in the “Heart By Numbers” special issue of Biophysical Journal which arose from a meeting in Berlin last year. They are all about IKr, the rapid-delayed rectifying … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , | 3 Comments

Short and rich voltage-clamp protocols

Posted on May 2, 2018 by Gary Mirams

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading →

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 8 Comments

In-silico Action Potential Prediction Web Portal

Posted on July 23, 2014 by Gary Mirams

This post is to announce that we are making our in-silico action potential prediction web portal (AP-predict) available for public use. The portal is free, you just need to register for an account. We’d be happy to have any feedback on … Continue reading →

Posted in Action Potential Models, Drug action, Safety Pharmacology | Tagged , , , , , , , | Leave a comment

Introducing the ‘Cardiac Electrophysiology Web Lab’

Posted on May 9, 2014 by Gary Mirams

I’m pleased to announce Jonathan Cooper and I have made our web portal interface to the cardiac electrophysiology virtual experiments publicly available. It’s called ‘Functional Curation for Cardiac Electrophysiology’, which is a bit of a mouthful, so I’m calling it … Continue reading →

Posted in Action Potential Models, Virtual Experiments | Tagged , , , , , , , , , , | 2 Comments