Tag Archives: Bayesian Inference

Our new review on fitting cardiac models

A reasonably short post to let you know about our recently published paper in WIREs Systems Biology and Medicine on parameter fitting in cardiac ion channel and action potential models with David Christini. There is an accessible introductory news article … Continue reading

Posted in Action Potential Models, Experimental Design, Ion Channel Models, Model Development, Stats and Inference, Uncategorized | Tagged , , , , , , , | Leave a comment

Job Available: Statistical inference for mechanistic models

N.B. Applications for this position are now closed. We are offering a 3 year position as a research fellow in statistical inference for mechanistic models. This is offered at either Postdoc or Senior postdoc level (equivalent grade to Assistant Professor) … Continue reading

Posted in Action Potential Models, Drug action, Experimental Design, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , , | Leave a comment

Three potassium channel modelling papers

Just a quick note to tell you about our latest batch of papers in the “Heart By Numbers” special issue of Biophysical Journal which arose from a meeting in Berlin last year. They are all about IKr, the rapid-delayed rectifying … Continue reading

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Numerics, Stats and Inference | Tagged , , , , , , , , , , , | 2 Comments

Numerical errors from ODE solvers can mess up optimisation and inference very easily

(Subtitle: “when you’ve got a lot of data points!”) This post is for people interested in doing optimisation or inference with Differential Equation (DE) models. If you are a statistician, you might be used to treating model simulators as black … Continue reading

Posted in Action Potential Models, Numerics, Stats and Inference | Tagged , , , , , , , | 7 Comments

Short and rich voltage-clamp protocols

This is a quick post to tell you all about Kylie’s new paper on sinusoidal-wave based voltage clamp protocols that has been published in the Journal of Physiology, and there’s an associated commentary from Ele Grandi. In the paper, some … Continue reading

Posted in Experimental Design, Future developments, Ion Channel Models, Model Development, Stats and Inference | Tagged , , , , , , , , , , , , | 7 Comments