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Tag Archives: Models
Hodgkin-Huxley models and Markov equivalents
Hodgkin & Huxley did some incredible work in the 1930s-50s on ion currents flowing through biological membranes. Despite not knowing what an ion channel was, they managed to work out an incredibly accurate predictive mathematical model for the currents that … Continue reading
Posted in Ion Channel Models
Tagged electrophysiology, Hodgkin-Huxley, ion channel, ion current, Markov, model construction, Models
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Is your model really ‘comprehensive’?
I’ve noticed more and more papers using the phrase “comprehensive model”. This phrase grates every time, and this post is about why. I thought this might just be me getting old and grumpy, so I plotted the mentions of the … Continue reading
Posted in Blog, Model Development, Silly
Tagged model comparison, model construction, Models, opinion, Silly, validation
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Hypotheses on hypotheses on …
(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading
On the importance of curating models
Most cardiac action potential models are published in a machine-readable markup language called CellML. This is a very good thing, because it unambiguously describes the system of equations that makes up the model, allows people to exchange and use them … Continue reading
Posted in Action Potential Models
Tagged Action potential, Cardiac electrophysiology, CellML, Functional Curation, Models, SED-ML
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Mathematical Matters of the Heart 