Category Archives: Action Potential Models

CiPA in-silico modelling meeting

There’s an effort underway to evaluate, improve and implement mathematical models of cardiac electrophysiology for pharmaceutical cardiac safety testing and regulatory practice. In particular, to be part of a more mechanistic and accurate in-vitro assessment of pro-arrhythmic risk than the … Continue reading

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Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?

On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased drug-induced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading

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Ablation, scars and insights from parameter lumping

This is quite a long post elaborating on a bit of work I’ve been doing with Greg Morley and his group, which was published in Scientific Reports. I hope it provides an accessible introduction to a fairly complicated set of experiments … Continue reading

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Are 30 compounds enough to test our simulations?

I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading

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Model Complexity

We’ve been thinking about how to parameterise/train/calibrate models, and also how to select an appropriate model to begin with. This raises all sorts of interesting questions on the details, but this post is just about setting out a big overview … Continue reading

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If computational biologists did astronomy…

Here is a cheeky post along the lines of Can a biologist fix a radio? (well worth a read). The discovery that Pluto wasn’t the size we expected got me thinking about how we would have tackled it. So in … Continue reading

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Triangles and Conductances

Just a little post on something that’s really simple, not new, and might seem obvious to some people – but might help when choosing how to explore the effect of altering parameters on action potential model behaviour. The reason I … Continue reading

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