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Category Archives: Action Potential Models
Arrhythmic risk: regression, single cell biophysics, or big tissue simulations?
On the 15th March I presented at an FDA public Advisory Committee hearing on the proposals of the CiPA initative. CiPA aims to replace the current testing for increased druginduced Torsade de Pointes (TdP) arrhythmic risk, which is a human … Continue reading
Ablation, scars and insights from parameter lumping
This is quite a long post elaborating on a bit of work I’ve been doing with Greg Morley and his group, which was published in Scientific Reports. I hope it provides an accessible introduction to a fairly complicated set of experiments … Continue reading
Are 30 compounds enough to test our simulations?
I’ve just contributed to a new review ‘Recent developments in using mechanistic cardiac modelling for drug safety evaluation’, which discusses where we are with using mathematical models of the electrical activity of cardiac muscle cells to predict whether new drugs … Continue reading
Model Complexity
We’ve been thinking about how to parameterise/train/calibrate models, and also how to select an appropriate model to begin with. This raises all sorts of interesting questions on the details, but this post is just about setting out a big overview … Continue reading
If computational biologists did astronomy…
Here is a cheeky post along the lines of Can a biologist fix a radio? (well worth a read). The discovery that Pluto wasn’t the size we expected got me thinking about how we would have tackled it. So in … Continue reading
Triangles and Conductances
Just a little post on something that’s really simple, not new, and might seem obvious to some people – but might help when choosing how to explore the effect of altering parameters on action potential model behaviour. The reason I … Continue reading
Hypotheses on hypotheses on …
(Subtitle: building on foundations of unknown shakiness?) In a lot of fields, a new mathematical model is constructed for each problem, and the model is an encoding of the quantitative rules of the hypothesis you are testing. The model is … Continue reading